Role of the Renin Angiotensin Aldosterone System in the Pathogenesis of Sepsis-Induced Acute Kidney Injury: A Systematic Review

Background: Sepsis is a life-threatening condition responsible for up to 20% of all global deaths. Kidneys are among the most common organs implicated, yet pathogenesis sepsis-induced acute kidney injury (S-AKI) not completely understood, resulting in treatment being nonspecific and responsive. In situations stress, renin angiotensin aldosterone system (RAAS) may play role. This systematic review focuses on analyzing impact RAAS development S-AKI discussing use antagonists as an emerging therapeutic option minimize complications sepsis. Methods: Studies were identified using electronic databases (Medline via PubMed, Google Scholar) published within past decade, comprised from 2014 2023. The search strategy was conducted following keywords: sepsis, S-AKI, RAAS, Angiotensin II, inhibitors. human animal subjects included if relevant keywords. Results: Our 22 eligible references pertaining inclusion criteria. Treatment sepsis with inhibitor medications observed decrease rates reduce severity offer improved prognosis septic patients. Conclusion: after onset has promising findings, evidence decreased renal tissue damage survival outcomes. Registration: INPLASY202360098.